•Patients with lung disease (e.g., COPD)•Patient has heart disease, irregular heart beat, or hypertension that is not well controlled•Patient is pregnant•Patient or caregiver is unwilling to administer autoinjectable epinephrine in the case of an emergency•Patient is receiving other AIT•Patient is taking medication that may enhance likelihood of severe allergic reactions or interfere with treatment of severe allergic reaction (i.e., beta-blockers, alpha-blockers, cardiac glycosides, diuretics, diphenhydramine, ergot alkaloids, MAOI or tricyclic antidepressants, thyroid hormone). The gene discussed is TG; the disease is Hypertension.