Nonetheless, ubiquitin-positive intracellular inclusions were initially found as the most frequent neuropathological correlate in susceptible regions in both diseases, and lately the phosphorylated form of TAR-DNA binding protein (TDP-43) was recognized as the principal compound of these ubiquitinated inclusions, pointing to a common pathological mechanism for FTD and ALS (Neumann et al., 2006). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.