PIP4K2A and acute myeloid leukemia: The promiscuity of the phosphoinositides in cellular signalling pathways has implications for disease as enzyme dysfunction or misregulation may be causative in various developmental disorders, inflammation and infection.13–16 As oncology targets, PI5P4Ks have become increasingly associated with a number of diseases.17 Interestingly the involvement of PI5P4Kα alone has been documented in glioblastoma, acute myeloid leukemia (AML) and prostate cancer18–21 but other examples suggest that there may be a combinatorial role for the PI5P4Ks.