To assess this, we first treated myeloma cells with ART and then evaluated a series of ferroptosis-related features, including the rescue effect of various cell death inhibitors, alterations in ROS and lipid peroxidation levels, changes in Fe2+ levels and their effects on ART-induced cell death, and changes in markers of ferroptosis, such as GPX4 and ACSL4. We found that at a specific concentration of ART, the inhibition of myeloma cell proliferation can be rescued by the ferroptosis-specific inhibitor Fer-1 but not by other types of cell death inhibitors. Here, GPX4 is linked to plasma cell myeloma.