In obese individuals, passive hypoxic exposure triggers beneficial cardiovascular and respiratory adaptations despite no alternation in anthropometric data.88 Combining exercise with hypoxic exposure is considered a promising supplementary approach for obesity management.89 Additionally, a 1-week exposure to high altitude (2,650m) without additional exercise showed weight reduction in obesity subjects.90 The suppression of appetite-related hormones, such as leptin, in hypoxic conditions contributes to a reduction in appetite and dietary energy intake, subsequently leading to weight loss. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.