Through inhibiting a number of important regulators of cell survival pathways, including AP-2, NF-κB, PI3K/Akt, and MAPK, and activating genes that are responsible for suppressing tumor-like p53 and PTEN (phosphatase and tensin homolog), resveratrol can inhibit cell proliferation, induce programmed cell death, and cell cycle transition disruption at the G1-S phase. The gene discussed is PTEN; the disease is neoplasm.