Using our multi‐omic network (including DHA affected and not affected genes in NASH), we ranked genes from the ERBB pathway based on their potential capacity to mediate effects of DHA and identified betacellulin (BTC), an alternative ligand of EGFR (Fig EV4A), as a top gene among the important genes (Grb2, Gsk3 Gsk3β/α, and Cbl) in the pathway (Fig 3C). Here, BTC is linked to metabolic dysfunction-associated steatohepatitis.