COL1A1 and metabolic dysfunction-associated steatohepatitis: Importantly, DHA prevents and reverses fibrosis in a NASH mouse model (Depner et al, 2013a; Lytle et al, 2015) and decreases expression of two out of three collagen encoding genes (COL1A1, COL1A2, COL4A1) that are upregulated in liver cancer and NASH (Appendix Fig S1D).