Importantly, DHA prevents and reverses fibrosis in a NASH mouse model (Depner et al, 2013a; Lytle et al, 2015) and decreases expression of two out of three collagen encoding genes (COL1A1, COL1A2, COL4A1) that are upregulated in liver cancer and NASH (Appendix Fig S1D). The gene discussed is COL4A1; the disease is metabolic dysfunction-associated steatohepatitis.