These results, along with a well‐known fact that a genetic deficiency of microbiota sensors (TLR2 and TLR4) attenuates NASH (Spruss et al, 2009; Miura et al, 2013; Wu et al, 2020), indicate that a reduction in TLR2 and/or TLR4 ligand levels by DHA might interact with the reduction of BTC in preventing the disease. The gene discussed is TLR2; the disease is metabolic dysfunction-associated steatohepatitis.