LDLR and metabolic dysfunction-associated steatohepatitis: For this, we evaluated histological markers of NASH (Dataset EV1a), transcriptomic, metabolomic, and lipidomic changes caused by DHA and EPA in the whole tissue liver samples from Ldlr−/− mice fed a western diet (WD) with the addition (or not) of DHA or EPA (Depner et al, 2013a; Fig 1A–C, Dataset EV1b).