Glucocorticoid-receptor resistance is linked to higher levels of stress and inflammatory mediators, and hence a sustained pro-inflammatory state (De Kloet et al., 2018; Glaser and Kiecolt-Glaser, 2015; Keller et al., 2017), including immune dysregulation of brain microglia (Wohleb et al., 2016), a characteristic feature of, in particular, atypical or a hypothesized immune-metabolic form of depression (Lamers et al., 2018). The gene discussed is NR3C1; the disease is depressive disorder.