Second, we have demonstrated that treating HGPS mice with ghrelin ameliorates the main age‐related histopathological alterations of mesenchymal tissues (Ribeiro et al., 2022), such as lipodystrophy, skin thinning, liver fibrosis, muscle atrophy, and aortic thinning, ultimately attenuating the age‐related functional decline, and extending the health and lifespan of progeria mice. This evidence concerns the gene GHRL and lipodystrophy.