As ghrelin and the fact that ghrelin and its analogues have already been used in several clinical trials as a therapeutic strategy for the treatment of conditions such as cachexia in chronic heart failure, frailty in the elderly, anorexia nervosa, growth hormone deficient patients (Akamizu & Kangawa, 2012; Strasser, 2012), the findings of this study provide ghrelin as an effective intervention to delay premature aging in HGPS and normal cellular aging, thus enhancing healthspan and lifespan. Here, GHRL is linked to Cachexia.