Furthermore, ghrelin decreased the frequency of nuclei with aberrant circularity (circularity < 0.6; 24.62 ± 10.92% in HGPS vs. 3.29 ± 0.82% in HGPS + Ghrelin) and an increased in the frequency of normal‐shaped nuclei (circularity > 0.8; 17.73 ± 2.32% in HGPS vs. 30.17 ± 6.81% in HGPS + ghrelin; Figure 2c), suggesting that ghrelin, likely through the prevention of progerin accumulation, improves abnormal nuclear morphology of HGPS cells. This evidence concerns the gene GHRL and Hutchinson-Gilford progeria syndrome.