In accordance with these data, high levels of TRF2 and NAMPT expression (TRF2High/NAMPTHigh) were found to correlate with a more aggressive tumor phenotype, as defined by the tumor stage, subtype and expression of estrogen receptor (ER), progesterone receptor (PR), HER2, and p53 (Figure S11). This evidence concerns the gene ERBB2 and neoplasm.