In accordance with these data, high levels of TRF2 and NAMPT expression (TRF2High/NAMPTHigh) were found to correlate with a more aggressive tumor phenotype, as defined by the tumor stage, subtype and expression of estrogen receptor (ER), progesterone receptor (PR), HER2, and p53 (Figure S11). The gene discussed is ESR1; the disease is neoplasm.