Studies have shown aspirin treatment impacts many other pathways including Wnt [43], NF-κB [44, 45], AMPK (adenosine monophosphate-activated protein kinase) and mTORC1 (mammalian target of rapamycin complex 1) [46, 47], as well as causing epigenetic alterations such as histone methylation [48, 49]; however, relatively little work has focused on the impact of aspirin treatment on cancer cell metabolism. Here, NFKB1 is linked to cancer.