HIF1A and neoplasm: Enriched canonical pathway terms that support the hypothesis that the MDM-B cluster is pro-angiogenic include glycolysis I (z-score of 2.45), tumor microenvironment (z-score of 3.16), and hypoxia inducible factor 1α (HIF1α, z-score of 2.83) signaling pathways (Fig. 7B).