SPP1 and neoplasm: Additionally, NR4A1 deficiency alters the transcriptional profile of classical MDMs toward a multimodal pro-angiogenic profile including increased glycolysis gene expression, HIF1a-driven Vegfa, Igf1, Mmp12, and Mmp14 expression, and upregulation of the tumor microenvironment pathway including Spp1, Cxcr4, and Csf1.