Some disorders have also been reclassified as CDG as the expansion of their pathophysiological mechanisms has included underlying glycosylation defects (e.g., Saul-Wilson syndrome [COG4], Cowden syndrome 7 [SEC23B], ALG5- and ALG9-CDG) [41]. This evidence concerns the gene COG4 and microcephalic osteodysplastic dysplasia, Saul-Wilson type.