In response to changes in the external environment of cervical cancer cells, such as inflammation, hypoxia, nutrient deficiency and acidosis, GRP78 is overexpressed and migrates to the surface of tumor cells, thereby generating a stress protective response by supporting the promotion of tumor growth and inducing drug resistance of tumor cells and playing an important role in the growth, development and diagnosis of cervical cancer. The gene discussed is HSPA5; the disease is cervical cancer.