CASP3 and cervical cancer: Moreover, studies have shown that compounds isolated from Sophora glycolipid species, which are obtained from plant matrix species by yeast, show toxic effects in HeLa and SiHa cervical cancer cells via inducing endoplasmic reticulum stress, upregulating GRP78 protein and promoting high expression of caspase 12 and caspase 3, ultimately inducing the apoptosis of cervical cancer cells.