It has been previous reported that ultrasound therapy significantly inhibits the proliferation and induces apoptosis of cervical cancer HeLa cells by activating endoplasmic reticulum stress (ERS), which is related to the apoptosis signaling pathway, as well as by triggering JNK phosphorylation and increasing the expression of GRP78 and caspase-12 [64]. This evidence concerns the gene HSPA5 and cervical cancer.