NFE2L2 and neoplasm: After intracellular delivery, TPL@TFBF released each component to perform its respective functions: with the help of TA, Fe3+ was reduced to Fe2+ in situ, leading to ROS production through the Fenton reaction, while TPL augmented intracellular ROS production by inhibiting Nrf2 expression, both of which increase intracellular ROS amplification to induce ferroptosis and pyroptosis, resulting in the release of large amounts of DAMPs to trigger a potent systemic anti-tumor immune response to inhibit tumor growth and lung metastasis.