At the same time, in combination with ST, researchers found that compared to the HMGA1 high-tumor stem cell subgroup in primary tumors, the HMGA1 high-tumor stem cell subgroup in lymph node metastasis has stronger proliferative potential, suggesting that a small number of HMGA1-high tumor stem cells that spread to lymph nodes can form lymph node metastasis through massive proliferation [13]. The gene discussed is HMGA1; the disease is neoplasm.