Further experiments showed that the lack of TREM2 can inhibit the growth of tumor-infiltrating macrophages, reduce the number of CX3CR1+ and MRC1+ macrophage subgroups, and enhance the reactivity of CD8+ T cells to anti-PD-L1, thereby remodeling the TME in mouse bone marrow metastasis [47]. The gene discussed is TREM2; the disease is neoplasm.