Sgubin M et al. demonstrated in a mouse model that, after silencing HMGA1, the metastatic activity of BC cells significantly decreased; this process was realized through the HMGA1/p27/stathmin axis, and the research results showed that after inducing HMGA1 depletion, the expression and activity of stathmin (an unstable phosphoprotein, which is overexpressed in metastatic tumors [21]) on microtubules were downregulated, leading to a decrease in microtubule dynamics, resulting in reduced mobility of TNBC cells and thus reduced tumor metastasis. The gene discussed is HMGA1; the disease is breast cancer.