The other marker gene L1CAM and its highly expressed gene ANGPTL4 in ARTN+L1CAM+epi_tum1 have also been proven to accelerate the hematogenous metastasis of tumor cells from the breast to the lung under hypoxic conditions by up-regulating the expression of hypoxia-inducible factor 1 subunit alpha (HIF1A) [2–4]. The gene discussed is HIF1A; the disease is neoplasm.