EDN1 and neoplasm: Analysis of intercellular communication showed that this hypoxia-related tumor subgroup in the TME can accelerate the formation of abnormal blood vessels and tumor progression by up-regulating various related signaling pathways such as ADM, VEGFA, EDN1, and ANGPTL4. In addition, Shi et al. [2] have confirmed that the marker genes ARTN and L1CAM of the hypoxia-related tumor cell subgroup are potential prognostic indicators of poor prognosis in triple-negative breast cancer (TNBC) patients.