More than 120 ALS-related genetic variants have been identified [15], including genetic mutations in C9orf72 (~ 40%, encoding chromosome 9 open reading frame 72), SOD1 (~ 12%, encoding superoxide dismutase 1), TARDBP (~ 5%; encoding TAR DNA-binding protein 43, TDP43), and FUS (~ 4%; encoding RNA binding protein fused in sarcoma) being the most common [16]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.