While the utilization of single-cell proteomics in ALS remains limited, a recent study described single-cell proteomic profiling of postmortem human spinal motor neurons from ALS patients, uncovering differential protein abundance profiles related to oxidative phosphorylation, mRNA splicing and translation, and retromer-mediated vesicular transport when comparing motor neurons with or without obvious TDP-43 cytoplasmic inclusions [219]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.