The results showed that, compared with the groups with no infection, the levels of miR-185 in mouse tissues (Fig. 1a, b), PK-15 cells (Fig. 1c, d) and 3D4/21 cells (Fig. 1e, f) were significantly elevated (t = 3.820, P < 0.05), whereas the mRNA levels of ARAF in mouse tissues (Fig. 2a, b), PK-15 cells (Fig. 2c, d) and 3D4/21 cells (Fig. 2e, f) were significantly decreased (t = 8.563, P < 0.01). The gene discussed is ARAF; the disease is infection.