IGF1R and osteosarcoma: High levels of IGF-1R are seen on the membrane and/or the cytoplasm, and in the nucleus of numerous cancer cell types including prostate cancer [35], head and neck squamous cell cancer [36], breast cancer [37], pancreatic cancer [38], colorectal cancer [39], non-small cell lung cancer [40], Ewing sarcoma [41], and osteosarcoma [42].