Up till now, about 5000 somatic mutations have been detected in prostate growth, and among these, the highly reported mutated genes are MED12, SCN11A, CDKN1B, SPOP, PIK3CA, PTEN, THSD7B, C14orf49, NIPA2, TP53, FOXA1, and ZNF595. Almost 15–25% risk of PCa is found in individuals having mutations in the BRCA gene, and life-threatening prostate cancer is reported to be linked with the mutations in BRCA1, BRCA2, and HOXB13 [28]. The gene discussed is SPOP; the disease is prostate cancer.