Furthermore, the production of TNF-α and IL-6 was reduced in Jurkat T cells overexpressing circPTPN22, which could be markedly rescued by miR-4689 transfection, suggesting that circPTPN22/miR-4689 plays a key role in modulating T-cell inflammation in SLE pathogenesis. The gene discussed is IL6; the disease is systemic lupus erythematosus.