Moreover, HMGB1, another RBP, plays a role in myocardial ischemia–reperfusion injury by triggering cardiomyocyte apoptosis through the TLR4 axis, promoting the release of cytokines and mediation of the inflammatory response via HMGB1/TLR4-related pathways [6]. This evidence concerns the gene HMGB1 and myocardial ischemia.