The increased expression of ZNF545 can inhibit the proliferation, migration and invasion of HCC cells, induce the G1/S phase arrest and apoptosis of SNU449 and Huh7 cells, and inhibit the tumor growth of SNU449 cell-xenografted mice, which is related to the inactivation of the Nf-κB signaling pathway [21]. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.