KCNA3 and irritable bowel syndrome: Most animal models of different CPP subclasses were built upon enhancing neuronal excitability, e.g., trinitrobenzene sulfonic acid (TNBS)-modified potassium channel for BMS [65], stress-based (cold, sound, or swim) approaches for fibromyalgia [66] or IBS [67], and electrical, physical or chemical stimulation of the trigeminal ganglion for chronic migraine [68].