CTSD and obstructive hydrocephalus: However, 10 proteins were found to be potential markers of treatment response in obstructive hydrocephalus (Fig. 3, right panel): ceruloplasmin (CP), cathepsin D (CTSD), coagulation factor 5 (F5), fibronectin (FN1), beta-hexosaminidase subunit beta (HEXB), hemopexin (HPX), serpin F member 1 (SERPINF1), selenoprotein M (SELENOM), serpin family A member 3 (SERPINA3), and sialate-O-acetylesterase (SIAE).