As demonstrated in Fig. 5B and C, IFN-γ could remarkably upregulate the phosphorylation of STAT1, and IFN-γ-induced STAT1 phosphorylation was significantly inhibited after blocking with total IgG from anti-IFN-γ IgG-positive SLE patients. The gene discussed is STAT1; the disease is systemic lupus erythematosus.