Notably, the levels of anti-IFN-γ IgG were positively correlated with SLEDAI score (r = 0.4942, p < 0.001), anti-dsDNA antibody levels (r = 0.2172, p = 0.0039), and ESR (r = 0.3855, p < 0.001) (Fig. 3A-C), indicating that the anti-IFN-γ IgG levels might be associated with SLE disease activity. The gene discussed is IFNG; the disease is systemic lupus erythematosus.