In addition, MDSCs may influence the immune function of CD8+ T cells through transcription factors: Marigo's experimental study found that the immunomodulatory activity of MDSC was dependent on C/EBP-β transcription factors, and the immune tolerance of CD8+ T cells was reversed after C/EBP-β was cleared from the bone marrow of tumor mice [88]. Here, CEBPB is linked to neoplasm.