Importantly, TRPM8 is involved in various processes that are related to cancer progression, suggesting that its ligands can exert anticancer activity in tissues that express TRPM8, such as breast cancer, bladder cancer, esophageal cancer, lung cancer, skin cancer, pancreatic cancer, colon cancer, gastric cancer, and osteosarcoma5. The gene discussed is TRPM8; the disease is esophageal cancer.