Upon restoration of MHC-I expression in GBM, the proportion of CD8+ cells in tumour tissues from imsEV-treated mice also increased (Fig. 6i, j, and Supplementary Fig. 25a), and the upregulation of IFN-γ was associated with increased proportions of M1-type macrophages at the tumour site (Fig. 6k and Supplementary Fig. 25b). The gene discussed is CD8A; the disease is glioblastoma.