KCNQ2 and ethylmalonic encephalopathy: Mutations in the KCNQ2 or KCNQ3 lead to hyper-excitation of neurons and the occurrence of seizures, such as benign familial neonatal seizures (BFNS or BFNE)8,9 and epileptic encephalopathy (EE)10–12, making KCNQ2 an important target of antiepileptic drugs13–15.