Mutations in the KCNQ2 or KCNQ3 lead to hyper-excitation of neurons and the occurrence of seizures, such as benign familial neonatal seizures (BFNS or BFNE)8,9 and epileptic encephalopathy (EE)10–12, making KCNQ2 an important target of antiepileptic drugs13–15. The gene discussed is KCNQ2; the disease is benign neonatal seizures.