Elevated levels of FGF23 in CKD have been associated with CVD and mortality, although the mechanism of risk marked by FGF23 is not fully understood.9 BAP is essential for bone mineralization and has also been associated with vascular calcification and mortality in CKD.10,11 Collagen 1 is the most abundant component in human bone. This evidence concerns the gene FGF23 and calcification.