RNF13 and metabolic dysfunction-associated steatohepatitis: To further confirm the impacts of RNF13 on NASH progression, we also generated hepatic Rnf13-overexpressed transgenic mice (Rnf13HepTg) and non-transgenic mice (Rnf13NTg) via the Sleeping Beauty transposon system23 (Supplementary Fig. 3d).