RNF13 and metabolic dysfunction-associated steatohepatitis: Furthermore, we proved STING is the downstream target of RNF13 in NASH, since RNF13 overexpression in hepatocytes can suppress STING protein level as well as the activation of its downstream signaling; the adenovirus-mediated STING overexpression significantly restored severe lipid deposition and inflammatory response in RNF13-overexpressed hepatocytes.