NPPA and cardiac hypertrophy: As shown in Fig. 8b and Supplementary Fig. 8b, ISO not only stimulated the expression of the hypertrophy biomarkers ANP, BNP, and β-MHC but also increased the level of lnc4012 in a dose-dependent manner, indicating that upregulation of lnc4012 is indeed closely correlated with the increased hypertrophic gene transcription and the development of myocardial hypertrophy.