AGT and myocardial infarction: MI-induced cardiomyocytes hypertrophy in the remote area is driven mainly by the neuroendocrine activation.1,2 Therefore, consistent with the pathophysiologic mechanism of in vivo MI-induced hypertrophy model, isoproterenol (ISO), Ang II or phenylephrine (PE) stimulated cardiomyocytes were used as in vitro hypertrophy model.