Previous studies have reported that G3BP2 might be able to bind to IκBα, which in turn promotes nuclear aggregation of the NF-κB subunit p65 to initiate the hypertrophic gene transcription and induces myocardial hypertrophy.33,34 But it is not known why and how the binding of G3BP2 to IκBα is increased during the development of myocardial hypertrophy. The gene discussed is G3BP2; the disease is cardiac hypertrophy.