We also discovered a new HHQ16-regulated Egr2-affiliated transcript lnc9456 and its human ortholog lnc4012 in the hypertrophied failing hearts of patients with dilated cardiomyopathy (DCM), and provided novel mechanistic insights into the roles of lnc4012/lnc9456 in the development of cardiac hypertrophy and HF. The gene discussed is EGR2; the disease is cardiac hypertrophy.