HHQ16 also significantly inhibited ISO, Ang II or ISO + PE induced high expression of lnc9456 in the primary or HL-1 cardiomyocytes (Fig. 3b, c), implicating that the effects of HHQ16 on cardiac hypertrophy and HF is associated with a strong inhibition of a new Egr2-affiliated transcript lnc9456. This evidence concerns the gene EGR2 and hydrops fetalis.