Pathological myocardial hypertrophy (PMH) is a dynamic maladaptive response of the heart to a variety of etiological stimuli, such as hypertension, MI, valvular heart disease, diabetes, and many others.2 Interestingly, Ang II or ISO-induced myocytes hypertrophy was abolished when lnc4012/lnc9456 was knocked down, indicating that pathological upregulation of lnc4012/lnc9456 might represent the downstream mediator for hypertrophic responses to neurohormonal activation. Here, AGT is linked to heart valve disorder.