G3BP2 and cardiac hypertrophy: In both in vivo animal models of lnc9456 overexpression- or LADL- induced cardiac hypertrophy (Supplementary Fig. 7a, b) and in vitro cell models of ISO- or ISO + PE- induced cardiomyocyte hypertrophy (Supplementary Fig. 7c, d), HHQ16 consistently caused a lnc9456-depedent reduction of G3BP2 in parallel with effective inhibition of hypertrophy.