KDR and central nervous system cancer: There is strong evidence supporting the role of VEGFR2 expression in the development of glioblastoma, including the promotion of tumour cell survival, invasion, and therapeutic resistance through autocrine signalling.78–83 While VEGFR2 expression may vary in all types of primary glioma,84 it appears that VEGFR expression may have an underestimated role within glioblastoma genetic signatures.