Therefore, this subtype may arise from a progenitor or neural stem cell in the oligodendrocyte lineage, such as PDGFRA-positive cells in the sub-ventricular zone, one of the main neurogenic regions in the adult brain.31,33 Bulk transcriptomics have enabled the prediction of intra-tumoural heterogeneity, allowing researchers to deconvolute an individual tumour to estimate the mixture of glioblastoma subtypes. The gene discussed is PDGFRA; the disease is glioblastoma.