Glioblastoma is a WHO grade IV adult-type, isocitrate dehydrogenase (IDH)-wildtype, diffuse astrocytic glioma.1 Although glioblastoma is a relatively rare diagnosis with 3–5 cases per 100,000 people, it is the most common form of high-grade glioma (HGG). The gene discussed is IDH1; the disease is central nervous system cancer.