FGFR1 and glioblastoma: However, in some glioblastoma patients, chromosomal translocations give rise to FGFR gene fusions between FGFR1 or FGFR3 and transforming acidic coiled-coil (TACC) proteins, generating FGFR-TACC fusion proteins that exhibit constitutively active kinase activity in glioblastoma cells.64 Furthermore, FGFR3 is significantly upregulated in infiltrating glioblastoma cells within the tumour periphery.65 In IDH-wildtype/FGFR-mutant glioblastomas, FGFR3 is the most commonly altered FGFR gene, including amplification and FGFR3-TACC3 fusions.66