DNER and glioblastoma: Histone modification, another well-characterised epigenetic mechanism, includes histone methylation, acetylation, phosphorylation, ubiquitination, and ADP-ribosylation.309 Histone acetylation and methylation are most relevant to glioblastoma tumourigenesis and are mediated by histone deacetylases (HDACs), histone methyltransferases and epigenetic reader proteins, mainly the bromodomain and extraterminal-containing protein family (BET).