Dysfunctional HIF‐1 signaling in cardiac tissue (an inability to stabilize HIF‐1α) has been implicated in the development of insulin resistance (Dodd et al., 2018), which suggests that HIF‐1 signaling and BNIP3 activation remain intact thereby removing oxidative damage caused during HFD induced obesity in female mice resulting in little to no mitochondrial defects. Here, BNIP3 is linked to obesity due to melanocortin 4 receptor deficiency.