To further illustrate the relationship between HLA-Iand proteasome genes, we correlate HLA-I with the expression of variouscomponents of the proteasome complex, including the 20S core particle,19S regulatory particle, 11S regulator, assembling chaperones, andproteasome-interacting proteins (PIPs) on both RNA and protein level.Besides PSMB8, PSMB9, and PSMB10, parts of the 20S core particle and11S regulator genes PSME1 and PSME2 are also highly correlated toHLA-I on both RNA and protein levels across all cancer types (Figure S8b). The gene discussed is PSME2; the disease is cancer.