CD274 and neoplasm: Indeed, it has been shown that STT3 was transcriptionallyinduced by epithelial–mesenchymal transition (EMT) throughβ-catenin, and STT3-dependent PD-L1 N-glycosylation stabilizesand upregulates PD-L1 in tumor cells.39 The mechanism of how HLA-I is involved has yet to be discovered.