Overall, allele frequencies of HLA-A andHLA-C are comparable to the expected values in most of the studies.A few HLA-I allele groups showed higher allele frequencies than expected(multitesting adjusted p value <0.05 and over50% higher than expected allele frequency) including B*13 in GBM,B*18 and C*12 in HNSCC, C*01 in LSCC, and B*15 in LUAD. Here, HLA-A is linked to head and neck squamous cell carcinoma.