Our current study identified the change of exosome and lipid metabolism-related genes with clinical value, and the 7-gene (ABCB1, CAP1, EGFR, ITGB1, MAPK1, PPARG, SNCA) prognostic formula is a novel and reliable predictive index in pancreatic cancer and other multiple cancers. Here, MAPK1 is linked to familial pancreatic carcinoma.