LDH-A is the isoform of lactate dehydrogenasewhich is overexpressed in cancer cells.4 It is fundamental for cancer cell proliferation because it preferentiallyconverts pyruvate into lactate.8,12 This reaction regeneratesthe NAD+ necessary for glycolysis and produces lactatethat behaves as a signaling molecule, allowing aerobic glycolysisto occur.11,13 Due to the role of lactate dehydrogenasein cancer cell proliferation, in recent years there has been an increasinginterest in the inhibition of LDH-A. This evidence concerns the gene LDHA and cancer.