Genes with evidence of differential transcript expression in inflamed FSHD muscle were enriched for autophagic processes, of significance given an elevated level of autophagic vacuoles found in a case series of atypical FSHD patients [91], and a potential role for DUX4 in autophagy [92]. The gene discussed is DUX4; the disease is facioscapulohumeral muscular dystrophy.