The results presented here suggest that (i) SARS-CoV-2 has limited ability to bind Jamaican fruit bat ACE2 (AjACE2) (poor susceptibility), which is consistent with a report demonstrating spike binding to AjACE2 [40]; (ii) it is unable to replicate in Jamaican fruit bat cells (poor permissibility); (iii) the innate response controls infection; or (iv) a combination of these features. Here, ACE2 is linked to infection.