For PAX6 and FOXC1, this is consistent with their broad expression patterns in the eye and the phenotypic heterogeneity and overlap linked to FOXC1 and PAX6 mutations, e.g., iris and corneal defects and higher prevalence of glaucoma [33,37], reinforcing a common regulatory network shared by the 2 TFs [81]. This evidence concerns the gene FOXC1 and glaucoma.