As for PAX6- and p63-associated disorders, although PAX6 and TP63 mutations are known to cause corneal opacity, other phenotypes are quite distinct, fully in line with their gene expression in different tissues, e.g., PAX6 in the cornea epithelium, iris, retina, pancreas, and parts of the central nervous system, and TP63 in the cornea epithelium, skin epidermis, and other stratified epithelia [20,33]. This evidence concerns the gene TP63 and Corneal opacity.