APOE and early-onset autosomal dominant Alzheimer disease: In line with a previous analysis [9], we found that both Alzheimer’s disease and Alzheimer’s pathologic change can be predicted with high degree of accuracy (AUC of 0.89 and 0.66 respectively) through a combination of 7 variables (age, sex, APOE4 carriership, family history of dementia, BMI, MMSE score and white matter lesion hyperintensities).