SAE1 and obesity due to melanocortin 4 receptor deficiency: Interestingly, SUMO-activating enzyme subunit 1 (SAE1), which mediates ATP-dependent activation of small ubiquitin-like modifier (SUMO) proteins, was one of the least abundant proteins and TRASH domain-containing protein, which DMBA decreased in lean mice, was increased when obesity was present (Figure 1H).