In humans, the GPR84 expression levels in adipose tissue from obese and nondiabetic subjects were positively correlated with low-calorie diet intervention (Gene Expression Omnibus [GEO] GSE95640) (55) (Supplemental Figure 1A), suggesting a beneficial role for GPR84 in obesity. This evidence concerns the gene GPR84 and obesity due to melanocortin 4 receptor deficiency.