DES and limb-girdle muscular dystrophy: LGMD comprises two main subtypes based on the pattern of inheritance: the autosomal recessive (LGMD-AR) and the autosomal dominant (LGMD-AD), and each subtypes include many other forms according to the genetic cause of the disease that affects the production of muscular proteins in the sarcolemma and sarcoplasm in addition to other parts of muscle fiber like Desmin, Calpain-3, Dysferlin, Sarcoglycan, Titin, etc. Mutations in the genes encoding these proteins lead to wasting in the muscles of proximal limb, and cardiomyopathy is always associated with the disease.