DMD and Duchenne muscular dystrophy: Obviously, DMD is the most aggressive among all NMDs due to the absence of an important muscular protein “dystrophin” since the increased Ca2+ influx into the myocytes, due to the comprised integrity of the sarcolemma, consequently leads to Ca2+ overload inside the mitochondria that will end up with mitochondrial dysfunction and activation of apoptotic mechanisms that causes accelerated cellular death (Rybalka et al., 2014).