The mitophagy receptors BNIP3L/Nix [162] and FUNDC1 [163] are both mitochondrial outer membrane proteins containing the LC3 interaction region (LIR) that have been shown to mediate hypoxia-induced mitophagy and play important roles in mitophagy-induced by cerebral ischemia (Fig. 2). This evidence concerns the gene BNIP3L and brain ischemia.