AgNPs induce cellular ox lysosomal disorders to further activate the inflammatory body complex composed of NOD-like receptor (NLR) family, pyrin-domain-containing 3 (NLRP-3), apoptosis-associated speck-like (ASC) adapter protein, and Pro-caspase-1; this complex mediates caspase-1 activation, which not only promotes the formation and release of IL-1β and IL-18 to mediate inflammatory responses but also cleaves GSDM to allow the N-terminal domain of GSDMD to form pores in the plasma membrane and eventually lead to cell pyroptosis [50, 51]. This evidence concerns the gene PYCARD and lysosomal storage disease.