IRS1 and early-onset autosomal dominant Alzheimer disease: As a consequence, an inhibition of physiological p-IR Tyr1355 tyrosine phosphorylation, p-IRS1 tyrosine 896, p-AKT serine 473, and p-GSK3α/β serine 21/9 was observed, as well as increased phosphorylation of IRS1 Ser307, and there was a substantial increase in BACE-1, APP, β-CTF, α-CTF, Aβ 1-42 and phosphorylated tau proteins (S199, S396, T205, S214 and S404), which are pathological proteins associated with Alzheimer's disease (Wang et al. 2017).