INS and Hypoglycemia: Research from individuals using MDI therapy with CGM devices and connected insulin pen or cap devices shows that late or missed insulin boluses are associated with higher A1C.16,18 In a prospective, observational trial of 94 participants with T1D, the use of a connected insulin pen with CGM resulted in significant improvements in glycemia and a significant decrease in missed doses.13 In a systematic review, 20%–45% of participants on insulin therapy reported the mistiming of their insulin doses17 citing disrupted daily routines, social situations, and hypoglycemia avoidance as reasons.