Unbiased clustering and UMAP plots demonstrated that both normal and tumor cells formed a diagonal axis along UMAP1 and UMAP2 with groups of control and CBL0137-treated cells located most distantly from each other and a group of bleomycin-treated cells located between those two groups and closer to the control (Figures 3A and 4A), suggesting that ChrD has stronger effects on the cell transcriptome than DnaD. This evidence concerns the gene CHRD and neoplasm.